Misterio Mezcal Bar Happy Hour. Downtown

Misterio Mezcal Bar is in the Arts District at 1300 S Casino Center Blvd, Suite 150, with street parking around it, and it is worth timing your arrival for the start of happy hour, which runs Monday through Thursday from 4 to 7pm. Get in early and you will have the bartenders' attention while they walk you through the agave list.

This is a dedicated mezcal and tequila spot, not a margarita factory, and the selection goes deep into artisanal and aged bottles. During happy hour selected drinks are half off, which is the real value here since cutting a premium pour in half turns a splurge into something you can actually explore. The food backs it up: tacos are 2 for 1, nachos run $6, ceviche is $8 whether you go shrimp, fish, or mixed, and guacamole is $7.50. A few rounds of 2-for-1 tacos plus the nachos makes a full dinner while you taste your way through the menu.

The staff knows agave regions and production well and shares it without lecturing, so newcomers and spirits nerds both leave with something new. The room runs moody, with Day of the Dead touches and seating that invites you to linger over sips rather than pound shots. Note the Monday-through-Thursday window, so a weekend visit means full pricing. Bring someone curious about mezcal, or come solo and let the bar guide the night.